DEXAMPHETAMINE and METHYLPHENIDATE are medications used to treat Attention-deficit Hyperactivity Disorder (ADHD).
Dr Rege, Consultant Psychoiatrist, explains the differences.
#adhd #adderall #ritalin #vyvanse #dexamphetamine #methylphenidate #amfetamine
Methylphenidate (MPH)
Mechanism of Action:
Non-competitive blockage of dopamine reuptake by Methylphenidate, MPH (MPH), occurs when dopamine transporter is (DAT) or noradrenalinetransporter (NAT) are blocked. This results in increased levels of dopamine (and noradrenaline) in the synaptic cell cleft.
Amphetamine can be classified as a d and l-isomer.
The active isomer is the d-isomer.
Mechanisms of Action :
1. Competing with noradrenaline and dopamine at NAT, competitive inhibitor at DAT
2. VMAT
Competitive inhibitor3. Reversal of DAT.
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