Ketamine for depression - A Powerful but Tricky Solution

Ketamine is a very powerful anesthetic drug that’s made it’s way into psychiatry. In this video I talk in detail about how Ketamine is used to treat depression.

Ketamine is known on the street as special K. It’s a hallucinogen and induces dissociation which is a detachment from your environment. In clinical medicine, it’s a drug primarily used to start and maintain anesthesia.

In 2000 the first randomized controlled trial showed that Ketamine produced rapid improvement of depression. It’s not FDA approved yet for the use of depression. It’s going to take more studies AND we need more answers about long term safety. But currently we are using it as an IV infusion to treat depression. A new nasal spray was recently approved, called Spravato for treatment resistant depression. It is designed to be taken along with an antidepressant.

References
Ketamine as a Rapid-Acting Antidepressant: Promising Clinical and Basic Research
Andrew N. Tuck and Danish H. Ghazali. American Journal of Psychiatry Residents’ Journal 2017 12:3, 3-5

Canuso C, Singh J. et. al. Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study. American Journal of Psychiatry 2018 175:7, 620-630

Grunebaum, M et. al. Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial. American Journal of Psychiatry 2018 175:4, 327-335

Sanacora G, Frye MA, McDonald W, et al. A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders. JAMA Psychiatry. 2017;74(4): 399–405.

Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.

I upload every Wednesday at 9am, and sometimes have extra videos in between. Subscribe to my channel so you don’t miss a video 3

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Ketamine for depression - A Powerful but Tricky Solution

Ketamine is a very powerful anesthetic drug that’s made it’s way into psychiatry. This video explains how Ketamine can be used to treat depression.

On the streets, Ketamine is called special K. It is a hallucinogen that induces dissociation. This is a feeling of being detached from your surroundings. It is primarily used in clinical medicine to maintain and start anesthesia.

2000 The first controlled randomized trial to test Ketamine for depression showed a rapid improvement. The FDA has not yet approved it for use in depression. We need to do more research and get more information about the safety of long-term use. Currently, we use it for IV infusions to treat depression. A new nasal spray, Spravato, was approved recently for treatment resistant depression. It can be used in conjunction with an antidepressant.

References
The Rapid-Acting Antidepressant Ketamine: Promising Clinical Research
Andrew N. Tuck, and Danish H. Ghazali. American Journal of Psychiatry Residents’ Journal 2017 12:3, 3-5

Canuso C., Singh J. et. al. Placebo-controlled, double-blind, randomized study on the safety and efficacy of intranasal esketamine for rapid reduction of depression and suicidality in patients at imminent risk for suicide. American Journal of Psychiatry 2018 175:7, 620-630

Grunebaum, M et. al. Midazolam-Controlled Randomized Clinical Study on Ketamine and Suicidal Thoughts: Rapid Reduction in Major Depression. American Journal of Psychiatry 2018 175:4, 327-335

Sanacora G, Frye MA, McDonald W, et al. A Consensus Statement regarding the use of Ketamine for the treatment of mood disorders. JAMA Psychiatry. 2017;74(4): 399-405.

Disclaimer: The information contained on this channel is intended for education purposes only and does not constitute specific/personal medical advice. The videos and the answers to questions/comments do not create a doctor-patient relationship. These videos may be helpful for you if you are a patient of your own doctor.

Every Wednesday, I upload a video at 9am. Sometimes, there are additional videos. Subscribe to my channel to ensure you never miss a video.

https://adhdadulttreatment.com/ketamine-for-depression-a-powerful-but-tricky-solution/

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