Do Antidepressants Shrink Your Brain? No but Depression Does.

Do antidepressants shrink your brain? No, but depression does. This question is based on a viewer comment. I think it’s pretty common for people to believe this. But in actuality, the illness, major depression causes brain cell loss and antidepressants protect you from that brain cell loss. This is where we get the term “pseudodementia.” Depression can have profound effects on your memory and it’s a cumulative effect. The effect is greater with repeated episodes and episodes that go a long time without treatment or resolution.

References:

If you read some of these studies, you’ll notice they use the term “stress” a lot when talking about triggering depression. The “stress” in these studies is not having too much work to do or a demanding schedule, they are talking about stress hormones called glucocorticoids such as cortisol. High levels of these hormones contribute the the cellular changes that cause depression.

Sheline YI et. al., Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression. Journal of Neuroscience. 15 June 1999, 19 (12) 5034-5043

The protein involved in neuron loss
Ota K, Liu R, Voleti B, et al. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nature Medicine. 2014.

How antidepressants protect against cell loss
Duman RS. Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide. F1000Research. 2018;7:F1000 Faculty Rev-659. doi:10.12688/f1000research.14344.1.

Antidepressants increase BDNF
Watanabe K. et. al. Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 1;34(8):1450-4. doi: 10.1016/j.pnpbp.2010.07.036. Epub 2010 Aug 11.

Disclaimer: All of the information on this channel is for educational purposes and not intended to be specific/personal medical advice from me to you. Watching the videos or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, perhaps these videos can help prepare you for your discussion with your doctor.

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Carry out Antidepressants Shrink Your Brain? No however Depression Does.

Carry out antidepressants shrink your brain? No, however despair does. This question is in step with a viewer commentary. I judge it’s aesthetic fashioned for folks to have confidence this. Nonetheless in point of fact, the illness, main despair causes brain cell loss and antidepressants provide protection to you from that brain cell loss. Right here’s the set we get the time interval “pseudodementia.” Depression can possess profound ends to your memory and or no longer it’s a cumulative get. The get is elevated with repeated episodes and episodes that chase a truly very prolonged time with out therapy or resolution.

References:

Whenever you read moderately just a few these study, you’ll scrutinize they employ the time interval “stress” a lot when talking about triggering despair. The “stress” in these study is no longer having too important work to total or a anxious agenda, they are talking about stress hormones known as glucocorticoids equivalent to cortisol. High ranges of these hormones make contributions the the mobile adjustments that trigger despair.

Sheline YI et. al., Depression Length Nonetheless No longer Age Predicts Hippocampal Quantity Loss in Medically Healthy Girls with Recurrent Foremost Depression. Journal of Neuroscience. 15 June 1999, 19 (12) 5034-5043

The protein occupied with neuron loss
Ota K, Liu R, Voleti B, et al. REDD1 is fundamental for stress-precipitated synaptic loss and depressive habits. Nature Medication. 2014.

How antidepressants provide protection to against cell loss
Duman RS. Ketamine and fleet-acting antidepressants: a brand novel technology in the wrestle against despair and suicide. F1000Compare. 2018;7:F1000 College Rev-659. doi: 10.12688/f1000study.14344.1.

Antidepressants amplify BDNF
Watanabe K. et. al. Get of antidepressants on brain-derived neurotrophic part (BDNF) unencumber from platelets in the rats
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Dec 1;34(8): 1450-4. doi: 10.1016/j.pnpbp.2010.07.036. Epub 2010 Aug 11.

Disclaimer: The total working out on this channel is for educational purposes and no longer intended to be explicit/private clinical advice from me to you. Watching the videos or getting solutions to comments/query, does no longer assign a doctor-affected person relationship. Whenever you might per chance possess your have confidence physician, perhaps these videos can support prepare you to your discussion alongside with your physician.

I add every Wednesday at 9am, and in most cases possess extra videos in between. Subscribe to my channel so that you do not pass over a video 3

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