This problem of antidepressants making you feel worse can happen when we use it for anxiety or depression. You may feel more depressed if you continue to take antidepressants. However, this effect will wear off if you do not stop taking them. Anxiety is more problematic. It can increase anxiety and make it worse than before.
This medication is not recommended for treating anxiety. The effect is usually temporary, meaning that it disappears after a few days. Some people may experience persistent symptoms and need to discontinue the medication. However, it will usually disappear within a few days.
It happens.
Researchers at the University of North Carolina discovered another pathway that is activated by serotonin. One pathway is activated by serotonin, which helps with mood and anxiety. However, it also activates another pathway called corticotropin-releasing factor (also known as corticotrophin-releasing hormone). This hormone is usually released in response to stress and a perceived threat from the environment. This hormone activates your body’s fight/flight response, which is designed to protect you against a threat. If there is no threat, the adrenal response can be referred to as anxiety.
Researchers discovered that serotonin could trigger the stress response via corticotrophin hormone production. This discovery has led to the development of a drug that blocks the release of corticotrophin hormones during the initial phase. Once you are fully onboard with antidepressants, this drug will be available.
We start with a low dose and gradually increase it until we reach a therapeutic dose. Sometimes, we may use Benzodiazepine. Once you have been fully onboarded with your medication your doctor will taper you off of the benzodiazepine. You would then only need to take the antidepressant for your anxiety.
References
Catherine A. Marcinkiewcz. Christopher M. Mazzone. Giuseppe D’Agostino. Lindsay R. Halladay. Jeffrey F. DiBerto. Montserrat Navarro. Nathan Burnham. Claudia Cristiano. Gregory J. Tipton. Charu Ramakrishnan. Tamas Kozicz. Karl Deisseroth. Todd E. Thiele. Zoe A. McElligott. Andrew Holmes. Lora K. H. Heisler. Heisler. The extended amygdala contains a fear-promoting and anxiety-promoting circuit that is activated by serotonin. Nature, 2016; DOI: 10. 1038/nature19318
Li Z, Pfeiffer PN, Hoggatt KJ, et al. A retrospective cohort study of Veterans Affairs Health System patients suffering from depression to determine if there is an increase in anxiety after the initiation of antidepressants. Clin Ther. 2011;33(12): 1985-1992.e1.
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