This episode I describe the neural mechanisms that activate and control aggressive states and behaviors and the role of hormones—estrogen and testosterone—in mediating violent and/or competitive aggression. I also describe tools that can be used to modulate the factors that have been shown to ‘prime’ an individual for aggression, including sunlight, estrogen sensitivity, competition within social settings, and overall stress levels, and the hormone cortisol. I discuss how substances such as caffeine and alcohol can impact impulsive behaviors and how nutrition and supplementation can be used to regulate mood and aggression.
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Article Links
Photoperiod reverses the effects of estrogens on male aggression via genomic and nongenomic pathways: Z
Testosterone and occupational choice: actors, ministers, and other men: S
Age, Testosterone, and Behavior Among Female Prison Inmates: t
Testosterone Rapidly Increases Neural Reactivity to Threat in Healthy Men: A Novel Two-Step Pharmacological Challenge Paradigm: Q
Caffeinated and non-caffeinated alcohol use and indirect aggression: The impact of self-regulation: 3
Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder: 9
Functional identification of an aggression locus in the mouse hypothalamus (See “Supplementary information” for movies): B
Book Links
An Introduction to Behavioral Endocrinology 5th Edition: 9
The Nature of the Beast: How Emotions Guide Us: 3
Other Links
Mouse switching from mating behavior to aggressive behaviors upon stimulation of VMH: />VMH stimulation causes mouse to display aggressive behaviors toward an inanimate object (e.g., glove): />
Timestamps
00: 00: 00 Aggression, Types of Aggression
00: 03: 33 AG1 (Athletic Greens), ROKA, Helix Sleep
00: 08: 29 Neural Circuits for Aggression, “Hydraulic Pressure Model”
00: 15: 50 Brain Regions Controlling Aggression, Ventromedial Hypothalamus (VMH)
00: 22: 14 Psychiatric Disorders & Aggression
00: 23: 36 Stimulation of the VMH, Estrogen Receptors & Aggression
00: 31: 57 Neural Circuits Mediating Physical Acts of Aggression, Biting
00: 35: 56 Testosterone & Competitiveness/Estrogen & Aggression
00: 43: 00 Sunlight, Melatonin & Aggression
00: 45: 46 Cortisol, Serotonin & Aggressive Behaviors
00: 51: 56 Tool: Omega-3 Supplementation & Mood
00: 54: 18 Tool: Sunlight, Sauna & Cortisol Reduction
00: 55: 54 Tool: Ashwagandha & Cortisol Reduction
00: 57: 06 Tool: Seasonality/Sunlight, Genetic Variation in Estrogen Sensitivity
01: 00: 37 Testosterone & Aggression, Competitive Work Environments
01: 05: 07 Testosterone, Amygdala, Challenge & Effort
01: 09: 27 Caffeine, Alcohol & Impulsivity
01: 13: 15 Tool: Caffeinated Alcohol Beverages, Impulsivity & Aggression
01: 17: 18 Tool: ADHD, Acetyl-L Carnitine & Aggressive Behavior
01: 24: 10 Factors Affecting the “Hydraulic Pressure Model” of Aggression
01: 25: 44 Book by Dr. David Anderson, Aggression & Social Relationships
01: 27: 35 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Patreon, Momentous Supplements, Neural Network Newsletter, Instagram, Twitter
The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.
Title Card Photo Credit: Mike Blabac – m
http://medbusiness.net/understanding-controlling-aggression-huberman-lab-podcast-71/
Can ADHD meds like Adderall turn you into a better student with better grades?
Are Energy Drinks Really That Bad? M
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Gloria Joy Sherrod
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*What are ADHD meds?*
Most ADHD drugs are stimulants. They stimulate and activate your central nervous system within 15 or 20 minutes of popping a pill. Caffeine is a stimulant, but ADHD drugs are a LOT more powerful. Like Adderall, which is one of the most commonly prescribed stimulant medications in the U.S. The active ingredient is a version of amphetamine, which has been around for decades.
*What is ADHD?*
ADHD stands for attention deficit hyperactivity disorder, and it’s one of the most common mental health conditions in people under 18. It’s like having 100 tabs open on your browser, but in your brain, so you end up paying attention to the WRONG stuff instead of focusing on what you actually need to get done. In the U.S., Adderall is the most common drug prescribed to treat ADHD.
*How do ADHD drugs help people with ADHD?*
A lot of it has to do with a specific neurotransmitter in the brain that you’ve probably heard of before – dopamine. It’s key when it comes to your brain’s reward pathways. When you have a normal level of dopamine hanging out in the synapses of your brain, you’re able to maintain motivation when you’re doing something you’re not interested in. But for someone with ADHD, there’s less dopamine hanging out in the synapses. So, there’s less motivation to get things done. To get that dopamine level up, there’s more of a desire for short-term rewards. ADHD meds work by helping dopamine to stick around longer in the synapses. For people with ADHD, they can stay focused and avoid distractions, and that can be a total game-changer when it comes to getting stuff done at school or at work.
*So what happens when someone WITHOUT ADHD takes an ADHD drug like Adderall?*
Many studies in the lab don’t show that people without ADHD get any boost to their cognition when they take ADHD drugs, but real-life situations like exams and writing papers haven’t fully been tested. But many studies do show that these kinds of meds make you think you did better than you actually did. And there are worrisome side effects that can hurt you long term.
SOURCES
Use of smart drugs on the rise
Attention-deficit-hyperactivity disorder and reward deficiency syndrome
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Morning stimulant administration reduces sleep and overnight working memory improvement
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The impact of psychostimulants on sustained attention over a 24-h period
America’s First Amphetamine Epidemic
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Neurocognitive Effects of Adderall
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Objective and Subjective Cognitive Enhancing Effects of Mixed Amphetamine Salts in Healthy People
Just How Cognitive Is “Cognitive Enhancement”?
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CHAPTERS
0: 00 The Hype Around ADHD Drugs
0: 59 History of Stimulants
2: 52 History of ADHD
5: 41 Dopamine and ADHD
7: 20 The Non-ADHD Brain on Stimulants
#adhd #adhdmedication #adhdlife #adhdstrategies
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